[Use of acetomepregenol in the treatment of threatened habitual miscarriage]. / Primenenie atsetomepregenola v lechenii ugrozhaiushchego privychnogo vykidysha.

Monitoring for pregnancy development and treatment efficacy in 104 females treated with acetomepregenol for threatened recurrent abortion at 8 to 16 week of gestation was performed with the use of ultrasonic variations. Ultrasonic criteria characteristic of the aforementioned condition were established. The technique suggested was distinguished by high levels of sensitivity, simplicity, availability and safety for mother and fetus.

PIP: Therapeutic efficacy of acetomepregenol (synthetic progestogen) was evaluated in 104 women (average age was 28.3 years) with threatened habitual abortion at 7-16 weeks of gestation. The group included 69 primipara and 35 secundipara; 73 had a history of 2 miscarriages, 17 of 3 and 14 of 4. clinical manifestations of threatened abortion included lower back and abdominal pain, metrorrhagia, decrease in basal temperature (45.2%), and decrease in chorionic gonadotropin level in the urine (51.9%). Echographic examination indicated local thickening of the myometrium wall in 92% of the patients and increase in the internal diameter of the cervix uteri (2.3-2.6 cm, compared with 1.76 cm in normal pregnancy) in 52.9%. Acetomepregenol was given not earlier than 7-8 weeks of gestation in a daily dose of 0.5-1.5 mg. Total dose per course was 10-45 mg; daily dose was gradually tapered off to 0.26-0.125 mg. During the treatment, 77.9% of the patients showed alleviation or complete disappearance of pain (on day 2-4), 87.5% showed normalization of urinary chorionic gonadotropin levels (1.5-2 weeks after the onset of treatment), and 88.6% showed normalization of the basal temperature (on day 5-7). Treatment with acetomepregenol resulted in gradual disappearance of local thickening of the myometrium seen at ultrasonic examination and normalization of the internal diameter of the cervix uteri. Of 104 women treated with acetomepregenol during the 1st trimester, 87 gave birth to normal babies, 8 had miscarriage at 12-27 weeks of gestation, and 9 had premature labor. The only side-effect of acetomepregenol was nausea recorded in 24% of the patients.

[Interrelation between arterial hypertension and the data of their obstetrical and gynecological anamnesis in women aged 30 to 54--workers in a Moscow industrial enterprise]. / Izuchenie vzaimosviazi arterial'noi gipertonii s dannymi akusherskoginekologicheskogo anamneza u zhenshchin 30-54 let--rabotnits promyshlennogo predpriiatiia Moskvy.

The population studies carried out among women engaged in automotive industry have demonstrated the relationship between arterial hypertension (AH) and an aggravated obstetric and gynecological anamnesis. In climacteric women, AH has been found to occur twice as frequently as in those of the same age with preserved menstrual function.